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REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding

Overview of attention for article published in BMC Molecular and Cell Biology, April 2017
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Title
REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding
Published in
BMC Molecular and Cell Biology, April 2017
DOI 10.1186/s12900-017-0074-z
Pubmed ID
Authors

Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura, Kei Yura

Abstract

More than 7000 papers related to "protein refolding" have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for protein refolding, a survey in the structural life science communities showed a necessity for a comprehensive database for refolding techniques. We therefore have developed a new resource - "REFOLDdb" that collects refolding techniques into a single, searchable repository to help researchers develop refolding protocols for proteins of interest. We based our resource on the existing REFOLD database, which has not been updated since 2009. We redesigned the data format to be more concise, allowing consistent representations among data entries compared with the original REFOLD database. The remodeled data architecture enhances the search efficiency and improves the sustainability of the database. After an exhaustive literature search we added experimental refolding protocols from reports published 2009 to early 2017. In addition to this new data, we fully converted and integrated existing REFOLD data into our new resource. REFOLDdb contains 1877 entries as of March 17(th), 2017, and is freely available at http://p4d-info.nig.ac.jp/refolddb/ . REFOLDdb is a unique database for the life sciences research community, providing annotated information for designing new refolding protocols and customizing existing methodologies. We envisage that this resource will find wide utility across broad disciplines that rely on the production of pure, active, recombinant proteins. Furthermore, the database also provides a useful overview of the recent trends and statistics in refolding technology development.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 32%
Student > Ph. D. Student 6 16%
Student > Master 4 11%
Student > Bachelor 2 5%
Student > Doctoral Student 2 5%
Other 4 11%
Unknown 8 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 39%
Agricultural and Biological Sciences 7 18%
Chemical Engineering 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Computer Science 1 3%
Other 1 3%
Unknown 10 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2017.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from BMC Molecular and Cell Biology
#935
of 1,233 outputs
Outputs of similar age
#248,234
of 323,377 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#11
of 16 outputs
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