↓ Skip to main content

Animal models of attention-deficit hyperactivity disorder

Overview of attention for article published in Behavioral and Brain Functions, July 2005
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 X users
facebook
1 Facebook page

Citations

dimensions_citation
195 Dimensions

Readers on

mendeley
280 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Animal models of attention-deficit hyperactivity disorder
Published in
Behavioral and Brain Functions, July 2005
DOI 10.1186/1744-9081-1-9
Pubmed ID
Authors

Vivienne A Russell, Terje Sagvolden, Espen Borgå Johansen

Abstract

Although animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not. ADHD is a heterogeneous disorder. The relatively simple nervous systems of rodent models have enabled identification of neurobiological changes that underlie certain aspects of ADHD behaviour. Several animal models of ADHD suggest that the dopaminergic system is functionally impaired. Some animal models have decreased extracellular dopamine concentrations and upregulated postsynaptic dopamine D1 receptors (DRD1) while others have increased extracellular dopamine concentrations. In the latter case, dopamine pathways are suggested to be hyperactive. However, stimulus-evoked release of dopamine is often decreased in these models, which is consistent with impaired dopamine transmission. It is possible that the behavioural characteristics of ADHD result from impaired dopamine modulation of neurotransmission in cortico-striato-thalamo-cortical circuits. There is considerable evidence to suggest that the noradrenergic system is poorly controlled by hypofunctional alpha2-autoreceptors in some models, giving rise to inappropriately increased release of norepinephrine. Aspects of ADHD behaviour may result from an imbalance between increased noradrenergic and decreased dopaminergic regulation of neural circuits that involve the prefrontal cortex. Animal models of ADHD also suggest that neural circuits may be altered in the brains of children with ADHD. It is therefore of particular importance to study animal models of the disorder and not normal animals. Evidence obtained from animal models suggests that psychostimulants may not be acting on the dopamine transporter to produce the expected increase in extracellular dopamine concentration in ADHD. There is evidence to suggest that psychostimulants may decrease motor activity by increasing serotonin levels. In addition to providing unique insights into the neurobiology of ADHD, animal models are also being used to test new drugs that can be used to alleviate the symptoms of ADHD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Chile 2 <1%
Germany 1 <1%
Italy 1 <1%
South Africa 1 <1%
Netherlands 1 <1%
Mexico 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 268 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 52 19%
Student > Ph. D. Student 43 15%
Student > Master 40 14%
Student > Bachelor 31 11%
Student > Doctoral Student 15 5%
Other 52 19%
Unknown 47 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 60 21%
Neuroscience 58 21%
Psychology 35 13%
Medicine and Dentistry 32 11%
Biochemistry, Genetics and Molecular Biology 17 6%
Other 22 8%
Unknown 56 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#8,328,988
of 25,545,162 outputs
Outputs from Behavioral and Brain Functions
#140
of 416 outputs
Outputs of similar age
#24,629
of 70,563 outputs
Outputs of similar age from Behavioral and Brain Functions
#2
of 5 outputs
Altmetric has tracked 25,545,162 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 416 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,563 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.