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Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR

Overview of attention for article published in BMC Cell Biology, May 2013
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1 tweeter

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Title
Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR
Published in
BMC Cell Biology, May 2013
DOI 10.1186/1471-2121-14-26
Pubmed ID
23711233
Authors

Li-Li Yu, Kai Chang, Lin-Shan Lu, Dan Zhao, Jian Han, Ying-Ru Zheng, Yao-Hua Yan, Ping Yi, Jian-Xin Guo, Yuan-Guo Zhou, Ming Chen, Li

Abstract

H19 is a paternally imprinted gene that has been shown to be highly expressed in the trophoblast tissue. Results from previous studies have initiated a debate as to whether noncoding RNA H19 acts as a tumor suppressor or as a tumor promotor in trophoblast tissue. In the present study, we developed lentiviral vectors expressing H19-specific small interfering RNA (siRNA) to specifically block the expression of H19 in the human choriocarcinoma cell line JAR. Using this approach, we investigated the impact of the H19 gene on the proliferation, invasion and apoptosis of JAR cells. Moreover, we examined the effect of H19 knockdown on the expression of insulin-like growth factor 2 (IGF2), hairy and enhancer of split homologue-1 (HES-1) and dual-specific phosphatase 5 (DUSP5) genes.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 23%
Researcher 6 23%
Student > Master 3 12%
Professor 2 8%
Other 2 8%
Other 3 12%
Unknown 4 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 31%
Agricultural and Biological Sciences 6 23%
Medicine and Dentistry 4 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Materials Science 1 4%
Other 1 4%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2013.
All research outputs
#3,563,886
of 4,507,509 outputs
Outputs from BMC Cell Biology
#132
of 167 outputs
Outputs of similar age
#92,891
of 119,408 outputs
Outputs of similar age from BMC Cell Biology
#5
of 6 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 167 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,408 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.

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