Title |
Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas
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Published in |
BMC Cancer, December 2013
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DOI | 10.1186/1471-2407-13-603 |
Pubmed ID | |
Authors |
Quirinus JM Voorham, Jerry Janssen, Marianne Tijssen, Suzanne Snellenberg, Sandra Mongera, Nicole CT van Grieken, Heike Grabsch, Martin Kliment, Bjorn J Rembacken, Chris JJ Mulder, Manon van Engeland, Gerrit A Meijer, Renske DM Steenbergen, Beatriz Carvalho |
Abstract |
Nonpolypoid adenomas are a subgroup of colorectal adenomas that have been associated with a more aggressive clinical behaviour compared to their polypoid counterparts. A substantial proportion of nonpolypoid and polypoid adenomas lack APC mutations, APC methylation or chromosomal loss of the APC locus on chromosome 5q, suggesting the involvement of other Wnt-pathway genes. The present study investigated promoter methylation of several Wnt-pathway antagonists in both nonpolypoid and polypoid adenomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 25% |
Spain | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
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Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 25% |
Student > Ph. D. Student | 5 | 18% |
Student > Master | 3 | 11% |
Professor | 2 | 7% |
Student > Doctoral Student | 1 | 4% |
Other | 5 | 18% |
Unknown | 5 | 18% |
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Unspecified | 1 | 4% |
Other | 3 | 11% |
Unknown | 4 | 14% |