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Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury

Overview of attention for article published in BMC Musculoskeletal Disorders, December 2013
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Title
Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury
Published in
BMC Musculoskeletal Disorders, December 2013
DOI 10.1186/1471-2474-14-359
Pubmed ID
Authors

Claude H Côté, Patrice Bouchard, Nico van Rooijen, David Marsolais, Elise Duchesne

Abstract

Sequential accumulation of M1 and M2 macrophages is critical for skeletal muscle recovery after an acute injury. While M1 accumulation is believed to rely on monocyte infiltration, the mechanisms of M2 accumulation remain controversial, but could involve an infiltrating precursor. Yet, strong depletion of monocytes only partially impairs skeletal muscle healing, supporting the existence of alternative mechanisms to palliate the loss of infiltrating macrophage progenitors. The aims of this study are thus to investigate if proliferation occurs in macrophage subsets within injured skeletal muscles; and to determine if monocyte depletion leads to increased proliferation of macrophages after injury.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 73 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 35%
Researcher 14 19%
Student > Master 9 12%
Student > Doctoral Student 7 9%
Student > Bachelor 6 8%
Other 5 7%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 24%
Medicine and Dentistry 16 22%
Biochemistry, Genetics and Molecular Biology 10 14%
Immunology and Microbiology 6 8%
Neuroscience 5 7%
Other 9 12%
Unknown 10 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2013.
All research outputs
#17,706,524
of 22,736,112 outputs
Outputs from BMC Musculoskeletal Disorders
#2,886
of 4,032 outputs
Outputs of similar age
#222,216
of 306,126 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#54
of 86 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,032 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,126 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.