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chTLR4 pathway activation by Astragalus polysaccharide in bursa of Fabricius

Overview of attention for article published in BMC Veterinary Research, May 2017
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Mentioned by

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3 tweeters

Citations

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13 Dimensions

Readers on

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10 Mendeley
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Title
chTLR4 pathway activation by Astragalus polysaccharide in bursa of Fabricius
Published in
BMC Veterinary Research, May 2017
DOI 10.1186/s12917-017-1039-y
Pubmed ID
Authors

Zhang Ruili, Yu Qun, Shi Guangliang, Liu Rui, Zhang Weiqian, Zhao Xia, Li Guangxing, Ge Ming, Ruili Zhang, Qun Yu, Guangliang Shi, Rui Liu, Weiqian Zhang, Xia Zhao, Guangxing Li, Ming Ge

Abstract

The Toll-like receptor 4 (TLR4) pathway involves in the pathogen recognition and defense against infection in mammals. Considering that avian and mammalian TLR are differentially mediated, the action of a natural product on avian TLR4 pathway was unclear. High, medium and low doses of Astragalus polysaccharide (APS), were treated the chicken at 7-days-old age by gavage. The sIgA level in the intestinal fluid, the expression of chTLR4 mRNA/protein in bursa of Fabricius as well as the expression of downstream molecules of chTLR4 (chMyD88, chTRIF, chNF-κB, chIRF3, chIFN-β and chTNF-α) were measured on alternate days. The content of sIgA and the chTLR4 mRNA expression/protein level were increased in non-dose-dependent manner after APS supplement. Also, the expressions of a subset of MyD88-independent pathway genes were more than MyD88-independent, in particular with low doses of APS supplement for 7 days. These suggest that administration of APS activates chTLR4 pathway in bursa of Fabricius in MyD88-independent pathway. Meanwhile, low dose of APS shows better performance regarding the activation of chTLR4 and regulation of MyD88-independent pathway.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer 2 20%
Other 1 10%
Student > Bachelor 1 10%
Professor 1 10%
Student > Master 1 10%
Other 1 10%
Unknown 3 30%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 10%
Philosophy 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Agricultural and Biological Sciences 1 10%
Energy 1 10%
Other 2 20%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2017.
All research outputs
#6,932,089
of 12,059,719 outputs
Outputs from BMC Veterinary Research
#603
of 1,659 outputs
Outputs of similar age
#127,708
of 268,560 outputs
Outputs of similar age from BMC Veterinary Research
#47
of 77 outputs
Altmetric has tracked 12,059,719 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,659 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,560 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.