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Roles and functions of HIV-1 Tat protein in the CNS: an overview

Overview of attention for article published in Virology Journal, December 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
4 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
90 Dimensions

Readers on

mendeley
140 Mendeley
citeulike
1 CiteULike
Summary Blogs Twitter Facebook Dimensions citations
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Title
Roles and functions of HIV-1 Tat protein in the CNS: an overview
Published in
Virology Journal, December 2013
DOI 10.1186/1743-422x-10-358
Pubmed ID
24359561
Authors

Asen Bagashev, Bassel E Sawaya

Abstract

Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated neurocognitive disorders (HAND). HIV-1 Tat (a key HIV transactivator of transcription) protein is one of the first HIV proteins to be expressed after infection occurs and is absolutely required for the initiation of the HIV genome transcription. In addition to its canonical functions, various studies have shown the deleterious role of HIV-1 Tat in the development and progression of HAND. Within the CNS, only specific cell types can support productive viral replication (astrocytes and microglia), however Tat protein can be released form infected cells to affects HIV non-permissive cells such as neurons. Therefore, in this review, we will summarize the functions of HIV-1 Tat proteins in neural cells and its ability to promote HAND.

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Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
France 1 <1%
South Africa 1 <1%
Unknown 136 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 26%
Student > Bachelor 23 16%
Student > Master 22 16%
Researcher 15 11%
Student > Doctoral Student 12 9%
Other 19 14%
Unknown 13 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 20%
Agricultural and Biological Sciences 27 19%
Medicine and Dentistry 18 13%
Immunology and Microbiology 15 11%
Neuroscience 9 6%
Other 25 18%
Unknown 18 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2015.
All research outputs
#3,263,414
of 22,738,543 outputs
Outputs from Virology Journal
#315
of 3,035 outputs
Outputs of similar age
#40,147
of 306,115 outputs
Outputs of similar age from Virology Journal
#8
of 55 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,115 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.

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