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Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis

Overview of attention for article published in Arthritis Research & Therapy, April 2002
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

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9 Dimensions

Readers on

mendeley
10 Mendeley
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Title
Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis
Published in
Arthritis Research & Therapy, April 2002
DOI 10.1186/ar406
Pubmed ID
Authors

Egidija Sakiniene, L Vincent Collins

Abstract

Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone (PBN) has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and cloxacillin on the development of Staphylococcus aureus arthritis.Three days after Naval Medical Research Institute (NMRI) mice were infected intravenously with S. aureus LS-1, daily treatment was started with cloxacillin alone, PBN alone, or cloxacillin and PBN. Arthritis, weight loss and general condition were evaluated for each mouse, and joints were analyzed histopathologically. Systemic administration of PBN in conjunction with cloxacillin ameliorated the course of experimental S. aureus arthritis, as evidenced by an increased cure rate. Thus, combinatorial antioxidant plus antibiotic anti-inflammatory therapies represent a potentially efficacious approach to the management of septic arthritis.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 20%
Professor > Associate Professor 2 20%
Other 1 10%
Student > Ph. D. Student 1 10%
Researcher 1 10%
Other 2 20%
Unknown 1 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 30%
Immunology and Microbiology 2 20%
Social Sciences 1 10%
Chemistry 1 10%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#10,323,641
of 18,441,118 outputs
Outputs from Arthritis Research & Therapy
#1,619
of 2,670 outputs
Outputs of similar age
#129,870
of 280,403 outputs
Outputs of similar age from Arthritis Research & Therapy
#50
of 125 outputs
Altmetric has tracked 18,441,118 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,670 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,403 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.