↓ Skip to main content

Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation

Overview of attention for article published in Molecular Brain, December 2013
Altmetric Badge

Mentioned by

twitter
1 X user
facebook
1 Facebook page

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
42 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation
Published in
Molecular Brain, December 2013
DOI 10.1186/1756-6606-6-52
Pubmed ID
Authors

Liangwu Sun, Yingjun Zhao, Kun Zhou, Hudson H Freeze, Yun-wu Zhang, Huaxi Xu

Abstract

Congenital disorders of glycosylation (CDGs) are inherited diseases caused by glycosylation defects. Incorrectly glycosylated proteins induce protein misfolding and endoplasmic reticulum (ER) stress. The most common form of CDG, PMM2-CDG, is caused by deficiency in the cytosolic enzyme phosphomannomutase 2 (PMM2). Patients with PMM2-CDG exhibit a significantly reduced number of cerebellar Purkinje cells and granule cells. The molecular mechanism underlying the specific cerebellar neurodegeneration in PMM2-CDG, however, remains elusive.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Vietnam 1 2%
Unknown 40 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Student > Bachelor 7 17%
Student > Master 7 17%
Researcher 5 12%
Student > Doctoral Student 3 7%
Other 5 12%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 38%
Biochemistry, Genetics and Molecular Biology 9 21%
Neuroscience 4 10%
Medicine and Dentistry 3 7%
Psychology 1 2%
Other 3 7%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2014.
All research outputs
#17,708,224
of 22,738,543 outputs
Outputs from Molecular Brain
#744
of 1,103 outputs
Outputs of similar age
#223,329
of 306,912 outputs
Outputs of similar age from Molecular Brain
#18
of 30 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,912 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.