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Sex differences in insular cortex gyri responses to a brief static handgrip challenge

Overview of attention for article published in Biology of Sex Differences, April 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#23 of 530)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
10 news outlets
blogs
2 blogs
twitter
6 X users
googleplus
1 Google+ user
reddit
1 Redditor

Citations

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13 Dimensions

Readers on

mendeley
35 Mendeley
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Title
Sex differences in insular cortex gyri responses to a brief static handgrip challenge
Published in
Biology of Sex Differences, April 2017
DOI 10.1186/s13293-017-0135-9
Pubmed ID
Authors

Paul M. Macey, Nicholas S. Rieken, Jennifer A. Ogren, Katherine E. Macey, Rajesh Kumar, Ronald M. Harper

Abstract

Cardiovascular disease varies between sexes, suggesting male-female autonomic control differences. Insular gyri help coordinate autonomic regulation and show a sex-dependent response to a sympathetic challenge. We examined sex-related insular gyral responses to a short static handgrip exercise challenge eliciting parasympathetic withdrawal with functional magnetic resonance imaging (fMRI) during four 16-s challenges (80% maximum strength) in 23 healthy females (age; mean ± std 50 ± 8 years) and 40 males (46 ± 9 years). Heart rate (HR) and fMRI signals were compared with repeated measures ANOVA (P < 0.05). Additional analyses were performed with age and age interactions, as well as right-handed only subjects. Females showed higher resting HR than males, but smaller percent HR change increases to the challenges. All gyri showed fMRI patterns concurrent with an HR peak and decline to baseline. fMRI signals followed an anterior-posterior organization in both sexes, but lateralization varied by gyri and sex. All subjects showed greater signals in the anterior vs. posterior gyri (females 0.3%, males 0.15%). The middle gyri showed no lateralization in females but left-sided dominance in males (0.1%). The posterior gyri showed greater left than right activation in both sexes. The anterior-most gyri exhibited a prominent sex difference, with females showing a greater right-sided activation (0.2%) vs. males displaying a greater left-sided activation (0.15%). Age and handedness affected a minority of findings but did not alter the overall pattern of results. The anterior insula plays a greater role in cardiovascular regulation than posterior areas during a predominantly parasympathetic withdrawal challenge, with opposite lateralization between sexes. In females, the left anterior-most gyrus responded distinctly from other regions than males. Those sex-specific structural and functional brain patterns may contribute over time to variations in cardiovascular disease between the sexes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 26%
Student > Master 5 14%
Researcher 3 9%
Student > Bachelor 3 9%
Other 1 3%
Other 2 6%
Unknown 12 34%
Readers by discipline Count As %
Neuroscience 5 14%
Sports and Recreations 4 11%
Medicine and Dentistry 4 11%
Nursing and Health Professions 3 9%
Agricultural and Biological Sciences 2 6%
Other 4 11%
Unknown 13 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 88. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2023.
All research outputs
#458,839
of 24,464,848 outputs
Outputs from Biology of Sex Differences
#23
of 530 outputs
Outputs of similar age
#9,858
of 314,457 outputs
Outputs of similar age from Biology of Sex Differences
#2
of 12 outputs
Altmetric has tracked 24,464,848 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 530 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,457 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.