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Development of an Illumina-based ChIP-exonuclease method provides insight into FoxA1-DNA binding properties

Overview of attention for article published in Genome Biology, December 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

blogs
1 blog
twitter
15 X users
googleplus
1 Google+ user

Citations

dimensions_citation
77 Dimensions

Readers on

mendeley
154 Mendeley
citeulike
1 CiteULike
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Title
Development of an Illumina-based ChIP-exonuclease method provides insight into FoxA1-DNA binding properties
Published in
Genome Biology, December 2013
DOI 10.1186/gb-2013-14-12-r147
Pubmed ID
Authors

Aurelien A Serandour, Gordon D Brown, Joshua D Cohen, Jason S Carroll

Abstract

ChIP-exonuclease (ChIP-exo) is a modified ChIP-seq approach for high resolution mapping of transcription factor DNA sites. We describe an Illumina-based ChIP-exo method which provides a global improvement of the data quality of estrogen receptor (ER) ChIP and insights into the motif structure for key ER-associated factors. ChIP-exo of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which we term mesas. We show that mesas occur in multiple cellular contexts and exist as single or overlapping motifs. Our Illumina-based ChIP-exo provides high resolution mapping of transcription factor binding sites.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Spain 2 1%
United Kingdom 1 <1%
Germany 1 <1%
Norway 1 <1%
Canada 1 <1%
Unknown 145 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 51 33%
Researcher 47 31%
Student > Master 10 6%
Professor > Associate Professor 8 5%
Student > Bachelor 7 5%
Other 20 13%
Unknown 11 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 84 55%
Biochemistry, Genetics and Molecular Biology 42 27%
Medicine and Dentistry 6 4%
Computer Science 4 3%
Immunology and Microbiology 2 1%
Other 4 3%
Unknown 12 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#2,170,878
of 25,374,647 outputs
Outputs from Genome Biology
#1,816
of 4,467 outputs
Outputs of similar age
#24,181
of 320,114 outputs
Outputs of similar age from Genome Biology
#49
of 114 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,114 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.