Title |
Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis
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Published in |
Acta Neuropathologica Communications, December 2013
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DOI | 10.1186/2051-5960-1-84 |
Pubmed ID | |
Authors |
David W Hampton, Andrea Serio, Gareth Pryce, Sarah Al-Izki, Robin JM Franklin, Gavin Giovannoni, David Baker, Siddharthan Chandran |
Abstract |
Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal substrate of secondary progression. In contrast to the increasing number of effective anti-inflammatory disease modifying treatments for relapse-remitting disease, the absence of therapies for progressive disease represents a major unmet clinical need. This raises the unanswered question of whether elimination of clinical relapses will prevent subsequent progression and if so how early in the disease course should treatment be initiated. Experimental autoimmune encephalomyelitis in the Biozzi ABH mouse recapitulates the clinical and pathological features of multiple sclerosis including relapse-remitting episodes with inflammatory mediated demyelination and progressive disability with neurodegeneration. To address the relationship between inflammation and neurodegeneration we used an auto-immune tolerance strategy to eliminate clinical relapses in EAE in a manner analogous to the clinical effect of disease modifying treatments. |
X Demographics
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United Kingdom | 1 | 25% |
Nigeria | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 55 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 25% |
Student > Ph. D. Student | 13 | 23% |
Student > Master | 8 | 14% |
Student > Bachelor | 5 | 9% |
Other | 4 | 7% |
Other | 10 | 18% |
Unknown | 2 | 4% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 14 | 25% |
Medicine and Dentistry | 13 | 23% |
Neuroscience | 11 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Psychology | 2 | 4% |
Other | 5 | 9% |
Unknown | 7 | 13% |