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Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome

Overview of attention for article published in BMC Medical Genomics, December 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
71 Dimensions

Readers on

mendeley
89 Mendeley
citeulike
1 CiteULike
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Title
Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome
Published in
BMC Medical Genomics, December 2013
DOI 10.1186/1755-8794-6-58
Pubmed ID
Authors

Meaghan J Jones, Pau Farré, Lisa M McEwen, Julia L MacIsaac, Kim Watt, Sarah M Neumann, Eldon Emberly, Max S Cynader, Naznin Virji-Babul, Michael S Kobor

Abstract

The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer's Disease (AD). In addition, trisomies have been shown to disrupt normal epigenetic marks across the genome, perhaps in response to changes in gene dosage. We hypothesized that trisomy 21 would result in global epigenetic changes across all participants, and that DS patients with cognitive impairment would show an additional epigenetic signature.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 1%
Unknown 88 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 20%
Student > Bachelor 17 19%
Student > Master 14 16%
Researcher 14 16%
Other 6 7%
Other 13 15%
Unknown 7 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 34%
Biochemistry, Genetics and Molecular Biology 14 16%
Medicine and Dentistry 13 15%
Neuroscience 10 11%
Nursing and Health Professions 5 6%
Other 8 9%
Unknown 9 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2014.
All research outputs
#1,622,474
of 4,507,509 outputs
Outputs from BMC Medical Genomics
#104
of 310 outputs
Outputs of similar age
#35,127
of 122,103 outputs
Outputs of similar age from BMC Medical Genomics
#4
of 11 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 310 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,103 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.