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Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

Overview of attention for article published in Journal of Neuroinflammation, September 2010
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45 Mendeley
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Title
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease
Published in
Journal of Neuroinflammation, September 2010
DOI 10.1186/1742-2094-7-57
Pubmed ID
Authors

S Sakura Minami, Elkhansa Sidahmed, Saba Aid, Mika Shimoji, Takako Niikura, Italo Mocchetti, G William Rebeck, Jay S Prendergast, Chris Dealwis, Ronald Wetzel, Francesca Bosetti, Yasuji Matsuoka, Hyang-Sook Hoe, R Scott Turner

Abstract

Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scrutiny in clinical studies, but its application is limited by neuroinflammatory side effects (autoimmune encephalitis and vasogenic edema).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 43 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 29%
Student > Ph. D. Student 5 11%
Other 4 9%
Professor > Associate Professor 3 7%
Student > Doctoral Student 3 7%
Other 12 27%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 24%
Medicine and Dentistry 8 18%
Biochemistry, Genetics and Molecular Biology 4 9%
Neuroscience 3 7%
Unspecified 2 4%
Other 7 16%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2014.
All research outputs
#20,215,721
of 22,738,543 outputs
Outputs from Journal of Neuroinflammation
#2,295
of 2,617 outputs
Outputs of similar age
#93,483
of 98,613 outputs
Outputs of similar age from Journal of Neuroinflammation
#9
of 11 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,617 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,613 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.