Title |
Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200
|
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Published in |
Journal of Translational Medicine, January 2014
|
DOI | 10.1186/1479-5876-12-4 |
Pubmed ID | |
Authors |
Miharu Kobayashi, Carlos Salomon, Jorge Tapia, Sebastian E Illanes, Murray D Mitchell, Gregory E Rice |
Abstract |
The role of exosomes in the pathogenesis and metastatic spread of cancer remains to be fully elucidated. Recent studies support the hypothesis that the release of exosomes from cells modifies local extracellular conditions to promote cell growth and neovascularisation. In addition, exosomes may modify the phenotype of parent and/or target cell. For example, sequestration of signaling mediators into exosomes may reduce their intracellular bioavailability to the parent cell thereby altering cell phenotype and metastatic potential. The fusion of released exosomes with target cell and delivery may also modify cell function and activity. In this study, to further elucidate the role of exosomes in ovarian cancer, the release of exosomes from two ovarian cancer cell lines of different invasive capacity and their miRNA content of exosomes were compared. The hypothesis to be tested was that ovarian cancer cell invasiveness is associated with altered release of exosomes and discordant exosomal sequestration of miRNA. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 25% |
Australia | 1 | 25% |
Canada | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 2 | 1% |
United States | 2 | 1% |
Unknown | 177 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 44 | 24% |
Student > Ph. D. Student | 37 | 20% |
Other | 30 | 17% |
Student > Doctoral Student | 12 | 7% |
Student > Master | 12 | 7% |
Other | 31 | 17% |
Unknown | 15 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 78 | 43% |
Biochemistry, Genetics and Molecular Biology | 30 | 17% |
Medicine and Dentistry | 25 | 14% |
Engineering | 7 | 4% |
Chemistry | 6 | 3% |
Other | 13 | 7% |
Unknown | 22 | 12% |