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GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli

Overview of attention for article published in Molecular Cancer, January 2014
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Title
GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli
Published in
Molecular Cancer, January 2014
DOI 10.1186/1476-4598-13-4
Pubmed ID
Authors

Xia Zhan, Juan Wang, Yuan Liu, Yuanqiu Peng, Wenfu Tan

Abstract

Smoothened (Smo), which possesses a structural similarity with classic G-protein coupled receptors (GPCR), is the most important molecular target in Hedgehog (Hh) signaling system for developing anticancer drugs; however, whether Smo may transmit GPCR-like signaling to activate the canonical transcriptional factor Gli of Hh signaling system and consequently to be involved in the Gli-dependent biological events remains controversial.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 35%
Student > Ph. D. Student 9 24%
Student > Master 4 11%
Student > Bachelor 4 11%
Student > Doctoral Student 2 5%
Other 2 5%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 46%
Biochemistry, Genetics and Molecular Biology 7 19%
Medicine and Dentistry 5 14%
Business, Management and Accounting 1 3%
Immunology and Microbiology 1 3%
Other 3 8%
Unknown 3 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2014.
All research outputs
#20,486,341
of 25,176,926 outputs
Outputs from Molecular Cancer
#1,464
of 1,895 outputs
Outputs of similar age
#242,873
of 318,596 outputs
Outputs of similar age from Molecular Cancer
#30
of 46 outputs
Altmetric has tracked 25,176,926 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,895 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.