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Virus interference between H7N2 low pathogenic avian influenza virus and lentogenic Newcastle disease virus in experimental co-infections in chickens and turkeys

Overview of attention for article published in Veterinary Research, January 2014
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Mentioned by

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2 tweeters

Citations

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61 Dimensions

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61 Mendeley
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Title
Virus interference between H7N2 low pathogenic avian influenza virus and lentogenic Newcastle disease virus in experimental co-infections in chickens and turkeys
Published in
Veterinary Research, January 2014
DOI 10.1186/1297-9716-45-1
Pubmed ID
Authors

Mar Costa-Hurtado, Claudio L Afonso, Patti J Miller, Erica Spackman, Darrell R Kapczynski, David E Swayne, Eric Shepherd, Diane Smith, Aniko Zsak, Mary Pantin-Jackwood

Abstract

Low pathogenicity avian influenza virus (LPAIV) and lentogenic Newcastle disease virus (lNDV) are commonly reported causes of respiratory disease in poultry worldwide with similar clinical and pathobiological presentation. Co-infections do occur but are not easily detected, and the impact of co-infections on pathobiology is unknown. In this study chickens and turkeys were infected with a lNDV vaccine strain (LaSota) and a H7N2 LPAIV (A/turkey/VA/SEP-67/2002) simultaneously or sequentially three days apart. No clinical signs were observed in chickens co-infected with the lNDV and LPAIV or in chickens infected with the viruses individually. However, the pattern of virus shed was different with co-infected chickens, which excreted lower titers of lNDV and LPAIV at 2 and 3 days post inoculation (dpi) and higher titers at subsequent time points. All turkeys inoculated with the LPAIV, whether or not they were exposed to lNDV, presented mild clinical signs. Co-infection effects were more pronounced in turkeys than in chickens with reduction in the number of birds shedding virus and in virus titers, especially when LPAIV was followed by lNDV. In conclusion, co-infection of chickens or turkeys with lNDV and LPAIV affected the replication dynamics of these viruses but did not affect clinical signs. The effect on virus replication was different depending on the species and on the time of infection. These results suggest that infection with a heterologous virus may result in temporary competition for cell receptors or competent cells for replication, most likely interferon-mediated, which decreases with time.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 33%
Student > Master 8 13%
Student > Ph. D. Student 8 13%
Student > Bachelor 7 11%
Other 2 3%
Other 6 10%
Unknown 10 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 25%
Veterinary Science and Veterinary Medicine 12 20%
Medicine and Dentistry 8 13%
Biochemistry, Genetics and Molecular Biology 6 10%
Immunology and Microbiology 3 5%
Other 1 2%
Unknown 16 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2014.
All research outputs
#2,301,515
of 4,507,509 outputs
Outputs from Veterinary Research
#229
of 417 outputs
Outputs of similar age
#58,866
of 122,890 outputs
Outputs of similar age from Veterinary Research
#11
of 26 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,890 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.