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Comparative genomic analysis reveals genetic features related to the virulence of Bacillus cereus FORC_013

Overview of attention for article published in Gut Pathogens, May 2017
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Title
Comparative genomic analysis reveals genetic features related to the virulence of Bacillus cereus FORC_013
Published in
Gut Pathogens, May 2017
DOI 10.1186/s13099-017-0175-z
Pubmed ID
Authors

Hyun-Jin Koo, Sojin Ahn, Han Young Chung, Suyeon Kim, Kwondo Kim, Sangryeol Ryu, Ju-Hoon Lee, Sang Ho Choi, Heebal Kim

Abstract

Bacillus cereus is well known as a gastrointestinal pathogen that causes food-borne illness. In the present study, we sequenced the complete genome of B. cereus FORC_013 isolated from fried eel in South Korea. To extend our understanding of the genomic characteristics of FORC_013, we conducted a comparative analysis with the published genomes of other B. cereus strains. We fully assembled the single circular chromosome (5,418,913 bp) and one plasmid (259,749 bp); 5511 open reading frames (ORFs) and 283 ORFs were predicted for the chromosome and plasmid, respectively. Moreover, we detected that the enterotoxin (NHE, HBL, CytK) induces food-borne illness with diarrheal symptom, and that the pleiotropic regulator, along with other virulence factors, plays a role in surviving and biofilm formation. Through comparative analysis using the complete genome sequence of B. cereus FORC_013, we identified both positively selected genes related to virulence regulation and 224 strain-specific genes of FORC_013. Through genome analysis of B. cereus FORC_013, we identified multiple virulence factors that may contribute to pathogenicity. These results will provide insight into further studies regarding B. cereus pathogenesis mechanism at the genomic level.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 32%
Student > Ph. D. Student 3 16%
Lecturer > Senior Lecturer 1 5%
Student > Doctoral Student 1 5%
Researcher 1 5%
Other 1 5%
Unknown 6 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 47%
Biochemistry, Genetics and Molecular Biology 3 16%
Immunology and Microbiology 1 5%
Unknown 6 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2017.
All research outputs
#14,936,169
of 22,973,051 outputs
Outputs from Gut Pathogens
#265
of 524 outputs
Outputs of similar age
#184,742
of 309,986 outputs
Outputs of similar age from Gut Pathogens
#11
of 19 outputs
Altmetric has tracked 22,973,051 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 524 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,986 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.