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Membrane of Candida albicans as a target of berberine

Overview of attention for article published in BMC Complementary Medicine and Therapies, May 2017
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
Membrane of Candida albicans as a target of berberine
Published in
BMC Complementary Medicine and Therapies, May 2017
DOI 10.1186/s12906-017-1773-5
Pubmed ID
Authors

Nataša Zorić, Ivan Kosalec, Siniša Tomić, Ivan Bobnjarić, Mario Jug, Toni Vlainić, Josipa Vlainić

Abstract

We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species. The effects on membrane, morphological transition, synthesis of ergosterol and the consequent changes in membrane permeability have been studied. Polarization and lipid peroxidation level of the membrane following berberine treatment have been addressed. Minimal inhibitory concentration (MIC) of berberine against C. albicans was 17.75 μg/mL. Cytotoxic effect of berberine was concentration dependent, and in sub-MIC concentrations inhibit morphological transition of C. albicans cells to its filamentous form. Results showed that berberine affects synthesis of membrane ergosterol dose-dependently and induces increased membrane permeability causing loss of intracellular material to the outer space (DNA/protein leakage). Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane. Moreover, ROS levels were also increased following berberine treatment indicating further the possibility of membrane damage. Based on the obtained results it seems that berberine achieves its anti-Candida activity by affecting the cell membrane.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 93 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 12%
Other 8 9%
Student > Master 8 9%
Student > Bachelor 8 9%
Student > Doctoral Student 7 8%
Other 21 23%
Unknown 30 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 16%
Agricultural and Biological Sciences 11 12%
Medicine and Dentistry 9 10%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Immunology and Microbiology 6 6%
Other 11 12%
Unknown 35 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2023.
All research outputs
#13,543,747
of 23,367,368 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,474
of 3,684 outputs
Outputs of similar age
#156,369
of 314,694 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#48
of 137 outputs
Altmetric has tracked 23,367,368 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,684 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,694 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.