Title |
Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues
|
---|---|
Published in |
BMC Musculoskeletal Disorders, January 2014
|
DOI | 10.1186/1471-2474-15-9 |
Pubmed ID | |
Authors |
Alan R Blackburn, Mark W Hamrick, Norman Chutkan, Rajnikumar Sangani, Jennifer L Waller, Raymond Corpe, Puttur D Prasad, Carlos M Isales, Vadivel Ganapathy, Sadanand Fulzele |
Abstract |
Nutrient levels are known to influence the development of osteoarthritis (OA), presumably by modulating levels of matrix biosynthesis and degradation. These processes may be affected by ascorbic acid (AA), an antioxidant which acts as a cofactor for numerous biochemical reactions and is essential for post-translational modifications of collagen. In this study we examined the expression of SVCT2, the only known Sodium coupled vitamin C transporter isoform present in articular cartilage, in human articular cartilage explants derived from both normal and osteoarthritis articular cartilage. |
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