Title |
HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV
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Published in |
Retrovirology, January 2014
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DOI | 10.1186/1742-4690-11-2 |
Pubmed ID | |
Authors |
Marta García-Montojo, Belén de la Hera, Jezabel Varadé, Ana de la Encarnación, Iris Camacho, María Domínguez-Mozo, Ana Arias-Leal, Ángel García-Martínez, Ignacio Casanova, Guillermo Izquierdo, Miguel Lucas, Maria Fedetz, Antonio Alcina, Rafael Arroyo, Fuencisla Matesanz, Elena Urcelay, Roberto Alvarez-Lafuente |
Abstract |
Multiple Sclerosis (MS) is an autoimmune demyelinating disease that occurs more frequently in women than in men. Multiple Sclerosis Associated Retrovirus (MSRV) is a member of HERV-W, a multicopy human endogenous retroviral family repeatedly implicated in MS pathogenesis. MSRV envelope protein is elevated in the serum of MS patients and induces inflammation and demyelination but, in spite of this pathogenic potential, its exact genomic origin and mechanism of generation are unknown. A possible link between the HERV-W copy on chromosome Xq22.3, that contains an almost complete open reading frame, and the gender differential prevalence in MS has been suggested. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
United Kingdom | 3 | 38% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Scientists | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Canada | 1 | 1% |
Unknown | 63 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 18% |
Student > Ph. D. Student | 10 | 15% |
Student > Bachelor | 7 | 10% |
Other | 6 | 9% |
Student > Doctoral Student | 5 | 7% |
Other | 18 | 27% |
Unknown | 9 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 22% |
Agricultural and Biological Sciences | 15 | 22% |
Biochemistry, Genetics and Molecular Biology | 8 | 12% |
Neuroscience | 8 | 12% |
Immunology and Microbiology | 4 | 6% |
Other | 8 | 12% |
Unknown | 9 | 13% |