Title |
Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies
|
---|---|
Published in |
Journal of Neuroinflammation, January 2014
|
DOI | 10.1186/1742-2094-11-6 |
Pubmed ID | |
Authors |
Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola, Emanuela Esposito, Stacy Gladman, Ping Yip, John V Priestley, Adina T Michael-Titus, Salvatore Cuzzocrea |
Abstract |
Two families of polyunsaturated fatty acid (PUFA), omega-3 (ω-3) and omega-6 (ω-6), are required for physiological functions. The long chain ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have significant biological effects. In particular, DHA is a major component of cell membranes in the brain. It is also involved in neurotransmission. Spinal cord injury (SCI) is a highly devastating pathology that can lead to catastrophic dysfunction, with a significant reduction in the quality of life. Previous studies have shown that EPA and DHA can exert neuroprotective effects in SCI in mice and rats. The aim of this study was to analyze the mechanism of action of ω-3 PUFAs, such as DHA, in a mouse model of SCI, with a focus on the early pathophysiological processes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Romania | 1 | 1% |
Unknown | 83 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 20% |
Student > Ph. D. Student | 14 | 16% |
Researcher | 13 | 15% |
Student > Doctoral Student | 6 | 7% |
Student > Bachelor | 6 | 7% |
Other | 15 | 18% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 19% |
Agricultural and Biological Sciences | 14 | 16% |
Neuroscience | 13 | 15% |
Biochemistry, Genetics and Molecular Biology | 10 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 11 | 13% |
Unknown | 17 | 20% |