Title |
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation
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Published in |
BMC Pulmonary Medicine, January 2014
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DOI | 10.1186/1471-2466-14-3 |
Pubmed ID | |
Authors |
Joan P Blonder, Sarah C Mutka, Xicheng Sun, Jian Qiu, Lucia H Green, Navdeep K Mehra, Ramakrishna Boyanapalli, Michael Suniga, Kirsten Look, Chris Delany, Jane P Richards, Doug Looker, Charles Scoggin, Gary J Rosenthal |
Abstract |
S-nitrosoglutathione (GSNO) serves as a reservoir for nitric oxide (NO) and thus is a key homeostatic regulator of airway smooth muscle tone and inflammation. Decreased levels of GSNO in the lungs of asthmatics have been attributed to increased GSNO catabolism via GSNO reductase (GSNOR) leading to loss of GSNO- and NO- mediated bronchodilatory and anti-inflammatory actions. GSNOR inhibition with the novel small molecule, N6022, was explored as a therapeutic approach in an experimental model of asthma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 18% |
Student > Ph. D. Student | 9 | 18% |
Student > Master | 7 | 14% |
Other | 5 | 10% |
Professor > Associate Professor | 5 | 10% |
Other | 6 | 12% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 18% |
Agricultural and Biological Sciences | 7 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Immunology and Microbiology | 2 | 4% |
Other | 8 | 16% |
Unknown | 12 | 24% |