Title |
Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum
|
---|---|
Published in |
Molecular Autism, January 2014
|
DOI | 10.1186/2040-2392-5-3 |
Pubmed ID | |
Authors |
Catherine Edmonson, Mark N Ziats, Owen M Rennert |
Abstract |
The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not completely understood, but ASDs are thought to ultimately result from disrupted synaptogenesis. However, studies have also shown that glial cell numbers and function are abnormal in post-mortem brain tissue from autistic patients. Direct assessment of glial cells in post-mortem human brain tissue is technically challenging, limiting glial research in human ASD studies. Therefore, we attempted to determine if glial cell-type specific markers may be altered in autistic brain tissue in a manner that is consistent with known cellular findings, such that they could serve as a proxy for glial cell numbers and/or activation patterns. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 8% |
Spain | 1 | 8% |
Mexico | 1 | 8% |
United Kingdom | 1 | 8% |
Unknown | 9 | 69% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 92% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Unknown | 207 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 37 | 18% |
Researcher | 32 | 15% |
Student > Master | 27 | 13% |
Student > Bachelor | 20 | 10% |
Student > Doctoral Student | 14 | 7% |
Other | 33 | 16% |
Unknown | 47 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 53 | 25% |
Agricultural and Biological Sciences | 38 | 18% |
Biochemistry, Genetics and Molecular Biology | 23 | 11% |
Medicine and Dentistry | 17 | 8% |
Psychology | 11 | 5% |
Other | 16 | 8% |
Unknown | 52 | 25% |