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Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

Overview of attention for article published in BMC Neurology, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
2 blogs
twitter
5 tweeters

Citations

dimensions_citation
84 Dimensions

Readers on

mendeley
99 Mendeley
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Title
Effect of TTP488 in patients with mild to moderate Alzheimer’s disease
Published in
BMC Neurology, January 2014
DOI 10.1186/1471-2377-14-12
Pubmed ID
Authors

Aaron H Burstein, Imogene Grimes, Douglas R Galasko, Paul S Aisen, Marwan Sabbagh, Adnan MM Mjalli

Abstract

TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). A previous report describes decreased decline in ADAS-cog (delta = 3.1, p = 0.008 at 18 months, ANCOVA with multiple imputation), relative to placebo, following a 5 mg/day dose of TTP488. Acute, reversible cognitive worsening was seen with a 20 mg/day dose. The present study further evaluates the efficacy of TTP488 by subgroup analyses based on disease severity and concentration effect analysis.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Japan 1 1%
United States 1 1%
South Africa 1 1%
Unknown 94 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 17%
Student > Master 14 14%
Student > Ph. D. Student 12 12%
Other 12 12%
Student > Bachelor 10 10%
Other 15 15%
Unknown 19 19%
Readers by discipline Count As %
Medicine and Dentistry 25 25%
Pharmacology, Toxicology and Pharmaceutical Science 11 11%
Agricultural and Biological Sciences 10 10%
Biochemistry, Genetics and Molecular Biology 9 9%
Neuroscience 6 6%
Other 12 12%
Unknown 26 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2019.
All research outputs
#1,591,052
of 21,744,520 outputs
Outputs from BMC Neurology
#129
of 2,313 outputs
Outputs of similar age
#24,690
of 350,283 outputs
Outputs of similar age from BMC Neurology
#14
of 199 outputs
Altmetric has tracked 21,744,520 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,313 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,283 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 199 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.