Title |
The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
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Published in |
Journal of Translational Medicine, May 2017
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DOI | 10.1186/s12967-017-1212-x |
Pubmed ID | |
Authors |
Margherita Nannini, Milena Urbini, Annalisa Astolfi, Guido Biasco, Maria A. Pantaleo |
Abstract |
Recent advances in molecular biology have revolutionized the concept of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumors (GIST) than the past. Indeed, from being defined as GIST without KIT or PDGFRA mutations, we are now faced with the opposite scenario, where KIT/PDGFRA WT GIST are "positively" defined according to their specific molecular alterations. In particular, if until recently KIT/PDGFRA GIST without abnormalities of KIT, PDGFRA, SDH, and the RAS signaling pathway were referred as quadruple WT GIST, today also this small subset of GIST is emerging out as a group of heterogeneous distinct entities with multiple different molecular alterations. Therefore, given this still growing and rapidly evolving scenario, the progressive molecular fragmentation may inevitably lead over the time to the disappearance of KIT/PDGFRA WT GIST, destined to be singularly defined by their molecular fingerprint. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 24% |
Student > Bachelor | 4 | 12% |
Researcher | 4 | 12% |
Student > Postgraduate | 4 | 12% |
Student > Master | 2 | 6% |
Other | 3 | 9% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Neuroscience | 2 | 6% |
Other | 1 | 3% |
Unknown | 10 | 30% |