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Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein

Overview of attention for article published in Journal of Hematology & Oncology, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)

Mentioned by

twitter
9 tweeters

Citations

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49 Dimensions

Readers on

mendeley
55 Mendeley
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Title
Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein
Published in
Journal of Hematology & Oncology, January 2014
DOI 10.1186/1756-8722-7-8
Pubmed ID
Authors

Vivek Subbiah, Shannon N Westin, Kai Wang, Dejka Araujo, Wei-Lien Wang, Vincent A Miller, Jeffrey S Ross, Phillip J Stephens, Gary A Palmer, Siraj M Ali

Abstract

Oncologic patients who are extreme responders to molecularly targeted therapy provide an important opportunity to better understand the biologic basis of response and, in turn, inform clinical decision making. Malignant neoplasms with an uncertain histologic and immunohistochemical characterization present challenges both on initial diagnostic workups and then later in management, as current treatment algorithms are based on a morphologic diagnosis. Herein, we report a case of a difficult to characterize sarcoma-like lesion for which genomic profiling with clinical next generation sequencing (NGS) identified the molecular underpinnings of arrested progression(stable disease) under combination targeted therapy within a phase I clinical trial.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
United Kingdom 1 2%
Czechia 1 2%
Unknown 51 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 29%
Student > Bachelor 7 13%
Student > Ph. D. Student 6 11%
Other 5 9%
Student > Postgraduate 3 5%
Other 7 13%
Unknown 11 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 25%
Medicine and Dentistry 13 24%
Biochemistry, Genetics and Molecular Biology 8 15%
Nursing and Health Professions 2 4%
Social Sciences 1 2%
Other 3 5%
Unknown 14 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2022.
All research outputs
#5,881,425
of 21,685,809 outputs
Outputs from Journal of Hematology & Oncology
#368
of 1,119 outputs
Outputs of similar age
#68,954
of 287,482 outputs
Outputs of similar age from Journal of Hematology & Oncology
#1
of 1 outputs
Altmetric has tracked 21,685,809 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,119 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,482 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them