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Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

Overview of attention for article published in BMC Structural Biology, January 2014
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Mentioned by

peer_reviews
1 peer review site

Citations

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22 Dimensions

Readers on

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38 Mendeley
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Title
Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment
Published in
BMC Structural Biology, January 2014
DOI 10.1186/1472-6807-14-1
Pubmed ID
Authors

Patrick EF O’Rourke, Justyna Kalinowska-Tłuścik, Paul K Fyfe, Alice Dawson, William N Hunter

Abstract

2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol-2-phosphate to 2C-methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosphate in production of isoprenoid-precursors via the methylerythritol phosphate biosynthetic pathway. IspF is found in the protozoan Plasmodium falciparum, a parasite that causes cerebral malaria, as well as in many Gram-negative bacteria such as Burkholderia cenocepacia. IspF represents a potential target for development of broad-spectrum antimicrobial drugs since it is proven or inferred as essential in these pathogens and absent from mammals. Structural studies of IspF from these two important yet distinct pathogens, and comparisons with orthologues have been carried out to generate reagents, to support and inform a structure-based approach to early stage drug discovery.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 21%
Student > Master 6 16%
Student > Bachelor 4 11%
Researcher 3 8%
Professor > Associate Professor 3 8%
Other 9 24%
Unknown 5 13%
Readers by discipline Count As %
Chemistry 12 32%
Agricultural and Biological Sciences 5 13%
Biochemistry, Genetics and Molecular Biology 4 11%
Immunology and Microbiology 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 7 18%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2014.
All research outputs
#14,363,350
of 21,358,901 outputs
Outputs from BMC Structural Biology
#130
of 212 outputs
Outputs of similar age
#174,286
of 287,145 outputs
Outputs of similar age from BMC Structural Biology
#1
of 2 outputs
Altmetric has tracked 21,358,901 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 212 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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