Title |
Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines
|
---|---|
Published in |
Journal of Hematology & Oncology, January 2014
|
DOI | 10.1186/1756-8722-7-7 |
Pubmed ID | |
Authors |
Denise Niewerth, Gertjan JL Kaspers, Yehuda G Assaraf, Johan van Meerloo, Christopher J Kirk, Janet Anderl, Jonathan L Blank, Peter M van de Ven, Sonja Zweegman, Gerrit Jansen, Jacqueline Cloos |
Abstract |
Despite encouraging results with the proteasome inhibitor bortezomib in the treatment of hematologic malignancies, emergence of resistance can limit its efficacy, hence calling for novel strategies to overcome bortezomib-resistance. We previously showed that bortezomib-resistant human leukemia cell lines expressed significantly lower levels of immunoproteasome at the expense of constitutive proteasomes, which harbored point mutations in exon 2 of the PSMB5 gene encoding the β5 subunit. Here we investigated whether up-regulation of immunoproteasomes by exposure to interferon-γ restores sensitivity to bortezomib in myeloma and leukemia cell lines with acquired resistance to bortezomib. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 22% |
Student > Bachelor | 11 | 17% |
Researcher | 11 | 17% |
Student > Master | 10 | 16% |
Other | 4 | 6% |
Other | 4 | 6% |
Unknown | 10 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 28% |
Biochemistry, Genetics and Molecular Biology | 13 | 20% |
Medicine and Dentistry | 12 | 19% |
Chemistry | 4 | 6% |
Immunology and Microbiology | 3 | 5% |
Other | 2 | 3% |
Unknown | 12 | 19% |