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Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy

Overview of attention for article published in Orphanet Journal of Rare Diseases, May 2017
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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5 tweeters

Citations

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16 Dimensions

Readers on

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48 Mendeley
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Title
Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy
Published in
Orphanet Journal of Rare Diseases, May 2017
DOI 10.1186/s13023-017-0652-y
Pubmed ID
Authors

Cara A. Timpani, Alan Hayes, Emma Rybalka

Abstract

Duchenne Muscular Dystrophy is a rare and fatal neuromuscular disease in which the absence of dystrophin from the muscle membrane induces a secondary loss of neuronal nitric oxide synthase and the muscles capacity for endogenous nitric oxide synthesis. Since nitric oxide is a potent regulator of skeletal muscle metabolism, mass, function and regeneration, the loss of nitric oxide bioavailability is likely a key contributor to the chronic pathological wasting evident in Duchenne Muscular Dystrophy. As such, various therapeutic interventions to re-establish either the neuronal nitric oxide synthase protein deficit or the consequential loss of nitric oxide synthesis and bioavailability have been investigated in both animal models of Duchenne Muscular Dystrophy and in human clinical trials. Notably, the efficacy of these interventions are varied and not always translatable from animal model to human patients, highlighting a complex interplay of factors which determine the downstream modulatory effects of nitric oxide. We review these studies herein.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 25%
Student > Master 9 19%
Researcher 8 17%
Student > Ph. D. Student 5 10%
Student > Doctoral Student 2 4%
Other 7 15%
Unknown 5 10%
Readers by discipline Count As %
Medicine and Dentistry 12 25%
Biochemistry, Genetics and Molecular Biology 8 17%
Agricultural and Biological Sciences 5 10%
Nursing and Health Professions 3 6%
Sports and Recreations 3 6%
Other 8 17%
Unknown 9 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2017.
All research outputs
#3,012,830
of 11,332,834 outputs
Outputs from Orphanet Journal of Rare Diseases
#421
of 1,234 outputs
Outputs of similar age
#86,615
of 265,451 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#14
of 28 outputs
Altmetric has tracked 11,332,834 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,234 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.