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Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients

Overview of attention for article published in BMC Gastroenterology, April 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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1 blog

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52 Mendeley
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Title
Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients
Published in
BMC Gastroenterology, April 2016
DOI 10.1186/s12876-016-0461-0
Pubmed ID
Authors

Matthias Sauter, Georg Keilholz, Helmut Kranzbühler, Norbert Lombriser, Meher Prakash, Stephan R. Vavricka, Benjamin Misselwitz

Abstract

Incidence of anal carcinoma (AC) is increasing and timely diagnosis is critical for efficient therapy. However, there is a paucity of recent studies addressing clinical symptoms and physical findings of anal carcinoma. We performed a retrospective study reviewing history, symptoms and physical findings from 86 patients with newly diagnosed AC. We analyzed frequency of symptoms and physical findings according to T and TNM stage and their predictive value regarding tumor stage. Most patients presented with T2 (37 %) or T3 (29 %) cancer. 85 of 86 patients were symptomatic with anal bleeding (78 %), anal/perianal pain (63 %), weight loss (31 %) and foreign body sensation (22 %). 95 % of patients had ≥1 finding on physical examination including a visible tumor, palpable resistance and pain/blood during digital rectal examination. Patients with locally advanced disease (T3/T4) presented with more symptoms (p < 0.01) and more physical findings (p = 0.04) than patients with T1/T2 disease. On multivariate regression analysis perianal pain, painful defecation and weight loss were significantly associated with T3/T4 disease. Clinical symptoms and physical findings are present in nearly all AC patients. Pain referred to the perianal region, painful defecation and weight loss have predictive value for locally advanced disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Student > Ph. D. Student 7 13%
Student > Bachelor 6 12%
Other 3 6%
Researcher 3 6%
Other 7 13%
Unknown 18 35%
Readers by discipline Count As %
Medicine and Dentistry 20 38%
Nursing and Health Professions 2 4%
Unspecified 1 2%
Agricultural and Biological Sciences 1 2%
Business, Management and Accounting 1 2%
Other 2 4%
Unknown 25 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2017.
All research outputs
#5,699,232
of 22,974,684 outputs
Outputs from BMC Gastroenterology
#345
of 1,762 outputs
Outputs of similar age
#80,835
of 301,504 outputs
Outputs of similar age from BMC Gastroenterology
#7
of 17 outputs
Altmetric has tracked 22,974,684 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,762 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,504 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.