Title |
Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients
|
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Published in |
BMC Gastroenterology, April 2016
|
DOI | 10.1186/s12876-016-0461-0 |
Pubmed ID | |
Authors |
Matthias Sauter, Georg Keilholz, Helmut Kranzbühler, Norbert Lombriser, Meher Prakash, Stephan R. Vavricka, Benjamin Misselwitz |
Abstract |
Incidence of anal carcinoma (AC) is increasing and timely diagnosis is critical for efficient therapy. However, there is a paucity of recent studies addressing clinical symptoms and physical findings of anal carcinoma. We performed a retrospective study reviewing history, symptoms and physical findings from 86 patients with newly diagnosed AC. We analyzed frequency of symptoms and physical findings according to T and TNM stage and their predictive value regarding tumor stage. Most patients presented with T2 (37 %) or T3 (29 %) cancer. 85 of 86 patients were symptomatic with anal bleeding (78 %), anal/perianal pain (63 %), weight loss (31 %) and foreign body sensation (22 %). 95 % of patients had ≥1 finding on physical examination including a visible tumor, palpable resistance and pain/blood during digital rectal examination. Patients with locally advanced disease (T3/T4) presented with more symptoms (p < 0.01) and more physical findings (p = 0.04) than patients with T1/T2 disease. On multivariate regression analysis perianal pain, painful defecation and weight loss were significantly associated with T3/T4 disease. Clinical symptoms and physical findings are present in nearly all AC patients. Pain referred to the perianal region, painful defecation and weight loss have predictive value for locally advanced disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 15% |
Student > Ph. D. Student | 7 | 13% |
Student > Bachelor | 6 | 12% |
Other | 3 | 6% |
Researcher | 3 | 6% |
Other | 7 | 13% |
Unknown | 18 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 38% |
Nursing and Health Professions | 2 | 4% |
Unspecified | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 2 | 4% |
Unknown | 25 | 48% |