Title |
Intestinal microbiota in human health and disease: the impact of probiotics
|
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Published in |
Genes & Nutrition, May 2011
|
DOI | 10.1007/s12263-011-0229-7 |
Pubmed ID | |
Authors |
Jacoline Gerritsen, Hauke Smidt, Ger T. Rijkers, Willem M. de Vos |
Abstract |
The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for the application of high-throughput functional microbiomic approaches to determine the contribution of the intestinal microbiota to human health. Moreover, we review the association between dysbiosis of the microbiota and both intestinal and extra-intestinal diseases. Finally, we discuss the potential of probiotic microorganism to modulate the intestinal microbiota and thereby contribute to health and well-being. The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 33% |
United States | 2 | 22% |
Ireland | 1 | 11% |
Venezuela, Bolivarian Republic of | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Practitioners (doctors, other healthcare professionals) | 3 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | <1% |
United Kingdom | 4 | <1% |
Netherlands | 3 | <1% |
Argentina | 3 | <1% |
Portugal | 2 | <1% |
Belgium | 2 | <1% |
Germany | 2 | <1% |
France | 1 | <1% |
Italy | 1 | <1% |
Other | 7 | <1% |
Unknown | 1022 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 185 | 18% |
Student > Bachelor | 179 | 17% |
Student > Ph. D. Student | 169 | 16% |
Researcher | 131 | 12% |
Student > Doctoral Student | 71 | 7% |
Other | 135 | 13% |
Unknown | 184 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 328 | 31% |
Medicine and Dentistry | 137 | 13% |
Biochemistry, Genetics and Molecular Biology | 129 | 12% |
Immunology and Microbiology | 77 | 7% |
Nursing and Health Professions | 34 | 3% |
Other | 144 | 14% |
Unknown | 205 | 19% |