↓ Skip to main content

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation

Overview of attention for article published in Journal of Neuroinflammation, January 2014
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
54 Dimensions

Readers on

mendeley
69 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation
Published in
Journal of Neuroinflammation, January 2014
DOI 10.1186/1742-2094-11-10
Pubmed ID
Authors

Debayon Paul, Shujun Ge, Yen Lemire, Evan R Jellison, David R Serwanski, Nancy H Ruddle, Joel S Pachter

Abstract

Expression of chemokine CCL2 in the normal central nervous system (CNS) is nearly undetectable, but is significantly upregulated and drives neuroinflammation during experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis which is considered a contributing factor in the human disease. As astrocytes and brain microvascular endothelial cells (BMEC) forming the blood-brain barrier (BBB) are sources of CCL2 in EAE and other neuroinflammatory conditions, it is unclear if one or both CCL2 pools are critical to disease and by what mechanism(s).

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Germany 1 1%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 35%
Researcher 9 13%
Student > Master 8 12%
Student > Doctoral Student 6 9%
Student > Bachelor 4 6%
Other 10 14%
Unknown 8 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 25%
Medicine and Dentistry 11 16%
Biochemistry, Genetics and Molecular Biology 8 12%
Neuroscience 7 10%
Veterinary Science and Veterinary Medicine 3 4%
Other 12 17%
Unknown 11 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2014.
All research outputs
#18,360,179
of 22,739,983 outputs
Outputs from Journal of Neuroinflammation
#2,058
of 2,617 outputs
Outputs of similar age
#228,496
of 305,591 outputs
Outputs of similar age from Journal of Neuroinflammation
#50
of 62 outputs
Altmetric has tracked 22,739,983 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,617 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,591 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.