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Pepsinogen C expression, regulation and its relationship with cancer

Overview of attention for article published in Cancer Cell International, May 2017
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Mentioned by

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3 tweeters

Citations

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13 Dimensions

Readers on

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21 Mendeley
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Title
Pepsinogen C expression, regulation and its relationship with cancer
Published in
Cancer Cell International, May 2017
DOI 10.1186/s12935-017-0426-6
Pubmed ID
Authors

Shixuan Shen, Jingyi Jiang, Yuan

Abstract

Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC's functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC. Serum PGC, and PGA levels and the PGA/PGC ratio have satisfactory sensitivity, specificity and price-quality ratio for predicting high GC risk. Ectopic PGC expression is significantly increased in prostate cancer, breast cancer, ovary cancer and endometrial cancer. In those sex-related cancers high level PGC expression indicates better prognosis and longer survival. The regulation of PGC expression involves genetic and epigenetic alteration of the encoding PGC gene, hormones modulation and interactions between PGC with other transcription factors and protein kinases. More and more research evidence hinted that PGC has strong correlation with cancer. In the systematic review, we respectively elaborate the structure, potential physiological functions, expression characteristics and regulation of PGC, and especially focus on the relationship between PGC expression and cancer to highlight the role of PGC in the tumorigenesis and its application value in clinical practice.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Student > Bachelor 2 10%
Student > Ph. D. Student 2 10%
Other 2 10%
Student > Master 2 10%
Other 2 10%
Unknown 7 33%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Psychology 2 10%
Immunology and Microbiology 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 2 10%
Unknown 7 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2017.
All research outputs
#8,425,523
of 11,026,397 outputs
Outputs from Cancer Cell International
#189
of 404 outputs
Outputs of similar age
#173,810
of 265,008 outputs
Outputs of similar age from Cancer Cell International
#5
of 8 outputs
Altmetric has tracked 11,026,397 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 404 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,008 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.