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Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

Overview of attention for article published in Acta Neuropathologica Communications, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent

Citations

dimensions_citation
111 Dimensions

Readers on

mendeley
141 Mendeley

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Title
Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
Published in
Acta Neuropathologica Communications, January 2014
DOI 10.1186/2051-5960-2-9
Pubmed ID
24456642
Authors

Timothy A Couttas, Nupur Kain, Benjamin Daniels, Xin Ying Lim, Claire Shepherd, Jillian Kril, Russell Pickford, Hongyun Li, Brett Garner, Anthony S Don

Abstract

The greatest genetic risk factor for late-onset Alzheimer's disease (AD) is the ϵ4 allele of Apolipoprotein E (ApoE). ApoE regulates secretion of the potent neuroprotective signaling lipid Sphingosine 1-phosphate (S1P). S1P is derived by phosphorylation of sphingosine, catalysed by sphingosine kinases 1 and 2 (SphK1 and 2), and SphK1 positively regulates glutamate secretion and synaptic strength in hippocampal neurons. S1P and its receptor family have been subject to intense pharmacological interest in recent years, following approval of the immunomodulatory drug Fingolimod, an S1P mimetic, for relapsing multiple sclerosis.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Netherlands 1 <1%
Poland 1 <1%
Australia 1 <1%
Unknown 137 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 21%
Student > Ph. D. Student 25 18%
Student > Bachelor 14 10%
Student > Master 11 8%
Student > Doctoral Student 6 4%
Other 20 14%
Unknown 35 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 20%
Biochemistry, Genetics and Molecular Biology 17 12%
Neuroscience 16 11%
Medicine and Dentistry 11 8%
Pharmacology, Toxicology and Pharmaceutical Science 8 6%
Other 20 14%
Unknown 41 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2019.
All research outputs
#4,894,499
of 16,797,794 outputs
Outputs from Acta Neuropathologica Communications
#668
of 1,019 outputs
Outputs of similar age
#68,774
of 259,068 outputs
Outputs of similar age from Acta Neuropathologica Communications
#5
of 10 outputs
Altmetric has tracked 16,797,794 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,019 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,068 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.

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