Title |
Increased burst size in multiply infected cells can alter basic virus dynamics
|
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Published in |
Biology Direct, May 2012
|
DOI | 10.1186/1745-6150-7-16 |
Pubmed ID | |
Authors |
Kara W Cummings, David N Levy, Dominik Wodarz |
Abstract |
The dynamics of viral infections have been studied extensively in a variety of settings, both experimentally and with mathematical models. The majority of mathematical models assumes that only one virus can infect a given cell at a time. It is, however, clear that especially in the context of high viral load, cells can become infected with multiple copies of a virus, a process called coinfection. This has been best demonstrated experimentally for human immunodeficiency virus (HIV), although it is thought to be equally relevant for a number of other viral infections. In a previously explored mathematical model, the viral output from an infected cell does not depend on the number of viruses that reside in the cell, i.e. viral replication is limited by cellular rather than viral factors. In this case, basic virus dynamics properties are not altered by coinfection. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
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Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 30% |
Researcher | 7 | 19% |
Student > Master | 5 | 14% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 2 | 5% |
Other | 4 | 11% |
Unknown | 4 | 11% |
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Mathematics | 2 | 5% |
Other | 7 | 19% |
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