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Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules.

Overview of attention for article published in Biology Direct, August 2009
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Title
Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules.
Published in
Biology Direct, August 2009
DOI 10.1186/1745-6150-4-31
Pubmed ID
Authors

Dressel R, Guan K, Nolte J, Elsner L, Monecke S, Nayernia K, Hasenfuss G, Engel W

Abstract

Multipotent adult germ-line stem cells (maGSCs) represent a new pluripotent cell type that can be derived without genetic manipulation from spermatogonial stem cells (SSCs) present in adult testis. Similarly to induced pluripotent stem cells (iPSCs), they could provide a source of cellular grafts for new transplantation therapies of a broad variety of diseases. To test whether these stem cells can be rejected by the recipients, we have analyzed whether maGSCs and iPSCs can become targets for cytotoxic T lymphocytes (CTL) or whether they are protected, as previously proposed for embryonic stem cells (ESCs).

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Germany 1 2%
Australia 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 27%
Student > Ph. D. Student 13 25%
Student > Master 4 8%
Student > Postgraduate 4 8%
Professor 4 8%
Other 7 13%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 44%
Medicine and Dentistry 8 15%
Biochemistry, Genetics and Molecular Biology 5 10%
Veterinary Science and Veterinary Medicine 1 2%
Environmental Science 1 2%
Other 6 12%
Unknown 8 15%