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Accumulation of GC donor splice signals in mammals

Overview of attention for article published in Biology Direct, July 2008
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Accumulation of GC donor splice signals in mammals
Published in
Biology Direct, July 2008
DOI 10.1186/1745-6150-3-30
Pubmed ID

Alexander Churbanov, Stephen Winters-Hilt, Eugene V Koonin, Igor B Rogozin


The GT dinucleotide in the first two intron positions is the most conserved element of the U2 donor splice signals. However, in a small fraction of donor sites, GT is replaced by GC. A substantial enrichment of GC in donor sites of alternatively spliced genes has been observed previously in human, nematode and Arabidopsis, suggesting that GC signals are important for regulation of alternative splicing. We used parsimony analysis to reconstruct evolution of donor splice sites and inferred 298 GT > GC conversion events compared to 40 GC > GT conversion events in primate and rodent genomes. Thus, there was substantive accumulation of GC donor splice sites during the evolution of mammals. Accumulation of GC sites might have been driven by selection for alternative splicing.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Germany 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 33%
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Professor > Associate Professor 3 10%
Professor 3 10%
Other 5 17%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 63%
Biochemistry, Genetics and Molecular Biology 5 17%
Business, Management and Accounting 1 3%
Medicine and Dentistry 1 3%
Unknown 4 13%