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CRISPR transcript processing: a mechanism for generating a large number of small interfering RNAs

Overview of attention for article published in Biology Direct, July 2012
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Title
CRISPR transcript processing: a mechanism for generating a large number of small interfering RNAs
Published in
Biology Direct, July 2012
DOI 10.1186/1745-6150-7-24
Pubmed ID
Authors

Marko Djordjevic, Magdalena Djordjevic, Konstantin Severinov

Abstract

CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated sequences) is a recently discovered prokaryotic defense system against foreign DNA, including viruses and plasmids. CRISPR cassette is transcribed as a continuous transcript (pre-crRNA), which is processed by Cas proteins into small RNA molecules (crRNAs) that are responsible for defense against invading viruses. Experiments in E. coli report that overexpression of cas genes generates a large number of crRNAs, from only few pre-crRNAs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Germany 1 1%
Unknown 79 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 27%
Researcher 20 25%
Student > Master 8 10%
Professor > Associate Professor 6 7%
Student > Bachelor 5 6%
Other 10 12%
Unknown 10 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 52%
Biochemistry, Genetics and Molecular Biology 17 21%
Computer Science 4 5%
Physics and Astronomy 2 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 5 6%
Unknown 10 12%