Title |
Designing of interferon-gamma inducing MHC class-II binders
|
---|---|
Published in |
Biology Direct, December 2013
|
DOI | 10.1186/1745-6150-8-30 |
Pubmed ID | |
Authors |
Sandeep Kumar Dhanda, Pooja Vir, Gajendra PS Raghava |
Abstract |
The generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T helper cells play a substantial contribution in the control of infections such as caused by Mycobacterium tuberculosis. In the past, numerous methods have been developed for predicting MHC class II binders that can activate T-helper cells. Best of author's knowledge, no method has been developed so far that can predict the type of cytokine will be secreted by these MHC Class II binders or T-helper epitopes. In this study, an attempt has been made to predict the IFN-γ inducing peptides. The main dataset used in this study contains 3705 IFN-γ inducing and 6728 non-IFN-γ inducing MHC class II binders. Another dataset called IFNgOnly contains 4483 IFN-γ inducing epitopes and 2160 epitopes that induce other cytokine except IFN-γ. In addition we have alternate dataset that contains IFN-γ inducing and equal number of random peptides. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | <1% |
United States | 1 | <1% |
Unknown | 374 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 50 | 13% |
Researcher | 47 | 12% |
Student > Master | 40 | 11% |
Student > Ph. D. Student | 39 | 10% |
Student > Postgraduate | 12 | 3% |
Other | 45 | 12% |
Unknown | 144 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 88 | 23% |
Agricultural and Biological Sciences | 39 | 10% |
Immunology and Microbiology | 28 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
Engineering | 8 | 2% |
Other | 42 | 11% |
Unknown | 164 | 44% |