Title |
Distinct contextual roles for Notch signalling in skeletal muscle stem cells
|
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Published in |
BMC Developmental Biology, January 2014
|
DOI | 10.1186/1471-213x-14-2 |
Pubmed ID | |
Authors |
Philippos Mourikis, Shahragim Tajbakhsh |
Abstract |
Notch signalling acts in virtually every tissue during the lifetime of metazoans. Recent studies have pointed to multiple roles for Notch in stem cells during quiescence, proliferation, temporal specification, and maintenance of the niche architecture. Skeletal muscle has served as an excellent paradigm to examine these diverse roles as embryonic, foetal, and adult skeletal muscle stem cells have different molecular signatures and functional properties, reflecting their developmental specification during ontology. Notably, Notch signalling has emerged as a major regulator of all muscle stem cells. This review will provide an overview of Notch signalling during myogenic development and postnatally, and underscore the seemingly opposing contextual activities of Notch that have lead to a reassessment of its role in myogenesis. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Norway | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 161 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 38 | 23% |
Researcher | 37 | 22% |
Student > Master | 17 | 10% |
Student > Bachelor | 12 | 7% |
Student > Postgraduate | 12 | 7% |
Other | 26 | 16% |
Unknown | 25 | 15% |
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Medicine and Dentistry | 9 | 5% |
Immunology and Microbiology | 2 | 1% |
Engineering | 2 | 1% |
Other | 7 | 4% |
Unknown | 30 | 18% |