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Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion

Overview of attention for article published in Acta Neuropathologica Communications, January 2014
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Title
Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion
Published in
Acta Neuropathologica Communications, January 2014
DOI 10.1186/2051-5960-2-10
Pubmed ID
Authors

Ashirwad Merve, Adrian M Dubuc, Xinyu Zhang, Marc Remke, Patricia A Baxter, Xiao-Nan Li, Michael D Taylor, Silvia Marino

Abstract

Medulloblastoma is the most common intracranial childhood malignancy and a genetically heterogeneous disease. Despite recent advances, current therapeutic approaches are still associated with high morbidity and mortality. Recent molecular profiling has suggested the stratification of medulloblastoma from one single disease into four distinct subgroups namely: WNT Group (best prognosis), SHH Group (intermediate prognosis), Group 3 (worst prognosis) and Group 4 (intermediate prognosis). BMI1 is a Polycomb group repressor complex gene overexpressed across medulloblastoma subgroups but most significantly in Group 4 tumours. Bone morphogenetic proteins are morphogens belonging to TGF-β superfamily of growth factors, known to inhibit medulloblastoma cell proliferation and induce apoptosis.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Italy 2 3%
Sweden 1 2%
Canada 1 2%
Unknown 58 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 31%
Researcher 12 19%
Student > Bachelor 10 16%
Student > Master 7 11%
Other 3 5%
Other 7 11%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 39%
Biochemistry, Genetics and Molecular Biology 14 22%
Medicine and Dentistry 14 22%
Neuroscience 2 3%
Unknown 9 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2014.
All research outputs
#18,361,534
of 22,741,406 outputs
Outputs from Acta Neuropathologica Communications
#1,228
of 1,369 outputs
Outputs of similar age
#228,828
of 306,092 outputs
Outputs of similar age from Acta Neuropathologica Communications
#28
of 41 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,092 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.