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Mendeley readers
Attention Score in Context
| Title |
Modification of Cul1 regulates its association with proteasomal subunits
|
|---|---|
| Published in |
Cell Division, April 2006
|
| DOI | 10.1186/1747-1028-1-5 |
| Pubmed ID | |
| Authors |
Joanna Bloom, Angelo Peschiaroli, George DeMartino, Michele Pagano |
| Abstract |
Ubiquitylation targets proteins for degradation by the 26S proteasome. Some yeast and plant ubiquitin ligases, including the highly conserved SCF (Skp1/Cul1/F-box protein) complex, have been shown to associate with proteasomes. We sought to characterize interactions between SCF complexes and proteasomes in mammalian cells. We found that the binding of SCF complexes to proteasomes is conserved in higher eukaryotes. The Cul1 subunit associated with both sub-complexes of the proteasome, and high molecular weight forms of Cul1 bound to the 19S proteasome. Cul1 is ubiquitylated in vivo. Ubiquitylation of Cul1 promotes its binding to the S5a subunit of the 19S sub-complex without affecting Cul1 stability. The association of ubiquitylating enzymes with proteasomes may be an additional means to target ubiquitylated substrates for degradation. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 13 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 33% |
| Researcher | 3 | 20% |
| Professor | 3 | 20% |
| Professor > Associate Professor | 2 | 13% |
| Student > Bachelor | 1 | 7% |
| Other | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 53% |
| Biochemistry, Genetics and Molecular Biology | 3 | 20% |
| Psychology | 1 | 7% |
| Medicine and Dentistry | 1 | 7% |
| Unknown | 2 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2021.
All research outputs
#4,722,615
of 22,979,862 outputs
Outputs from Cell Division
#17
of 132 outputs
Outputs of similar age
#12,004
of 66,482 outputs
Outputs of similar age from Cell Division
#2
of 4 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,482 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.