Title |
A metabolic biosignature of early response to anti-tuberculosis treatment
|
---|---|
Published in |
BMC Infectious Diseases, January 2014
|
DOI | 10.1186/1471-2334-14-53 |
Pubmed ID | |
Authors |
Sebabrata Mahapatra, Ann M Hess, John L Johnson, Kathleen D Eisenach, Mary A DeGroote, Phineas Gitta, Moses L Joloba, Gilla Kaplan, Gerhard Walzl, W Henry Boom, John T Belisle |
Abstract |
The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium tuberculosis (Mtb) infection and the lack of early biomarkers to predict treatment outcome. Advancements in the field of metabolomics make it possible to identify metabolic profiles that correlate with disease states or successful chemotherapy. However, proof-of-concept of this approach has not been provided for a TB-early treatment response biosignature (TB-ETRB). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
South Africa | 1 | <1% |
Unknown | 121 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 32 | 26% |
Student > Ph. D. Student | 17 | 14% |
Student > Master | 13 | 10% |
Student > Bachelor | 13 | 10% |
Student > Postgraduate | 5 | 4% |
Other | 23 | 19% |
Unknown | 21 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 33 | 27% |
Agricultural and Biological Sciences | 22 | 18% |
Immunology and Microbiology | 15 | 12% |
Biochemistry, Genetics and Molecular Biology | 14 | 11% |
Computer Science | 2 | 2% |
Other | 14 | 11% |
Unknown | 24 | 19% |