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Evaluation of the safety and efficacy of a novel product for the removal of impacted human cerumen

Overview of attention for article published in BMC Ear, Nose and Throat Disorders, June 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)

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9 news outlets
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4 X users

Citations

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7 Dimensions

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48 Mendeley
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Title
Evaluation of the safety and efficacy of a novel product for the removal of impacted human cerumen
Published in
BMC Ear, Nose and Throat Disorders, June 2017
DOI 10.1186/s12901-017-0038-8
Pubmed ID
Authors

Douglas Fullington, Jenny Song, Antionette Gilles, Xiaowen Guo, Waley Hua, C. Eric Anderson, Joseph Griffin

Abstract

This open-label study evaluated the safety and efficacy of a novel product for the removal of impacted cerumen in adult patients. This was a prospective, single-center, single-arm, self-controlled clinical trial conducted in a community general practice setting. The novel product contains glycolic acid in an otologically-acceptable buffer containing sodium bicarbonate and glycerin and other buffering agents. The product was instilled into the ear canal prior to irrigation with warm water. Severity of cerumen impaction was graded using a 5-point scale. Improvement in tympanic membrane visualization was assessed after instillation and irrigation. A majority (83%, 25/30) of ears showed improvement with one application: with 53% (16/30) totally dissolved and gained 100% TM visualization. Total dissolution was observed in 80% (24/30) of the study ears per the intent-to-treat analysis and 86% (24/28) if irrigation instructions were followed. Most of the ears/participants that had cerumen blockage symptoms experienced significant improvement with the application. Feelings of fullness disappeared in 92% (11/12) of the affected ears; ears itching, 91% (10/11); water trapping or cracking, 78%, and decreased hearing disappeared in 71% (10/14). All (100%, 18) of the participants who completed the application satisfaction assessment were satisfied with the application process in terms of time needed and the overall rinse procedure. Only one mild adverse event (ear pruritis) occurred that was related to application. The tested cerumen removal product was effective and safe for removing moderate to severe blockage in patients with impacted cerumen. Procedure satisfaction for the product was high. This trial is registered on http://www.clinicaltrials.gov/. The registration number is NCT02829294. The trial was retrospectively registered on July 8, 2016.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 15%
Student > Postgraduate 4 8%
Other 4 8%
Student > Doctoral Student 3 6%
Researcher 3 6%
Other 8 17%
Unknown 19 40%
Readers by discipline Count As %
Medicine and Dentistry 15 31%
Nursing and Health Professions 5 10%
Biochemistry, Genetics and Molecular Biology 2 4%
Unspecified 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 5 10%
Unknown 18 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 74. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2022.
All research outputs
#485,615
of 22,792,160 outputs
Outputs from BMC Ear, Nose and Throat Disorders
#2
of 82 outputs
Outputs of similar age
#11,587
of 316,724 outputs
Outputs of similar age from BMC Ear, Nose and Throat Disorders
#1
of 3 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them