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Microarray expression profiling in the denervated hippocampus identifies long noncoding RNAs functionally involved in neurogenesis

Overview of attention for article published in BMC Molecular Biology, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#23 of 278)
  • Good Attention Score compared to outputs of the same age (77th percentile)

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1 blog
twitter
1 tweeter

Citations

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15 Dimensions

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10 Mendeley
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Title
Microarray expression profiling in the denervated hippocampus identifies long noncoding RNAs functionally involved in neurogenesis
Published in
BMC Molecular Biology, June 2017
DOI 10.1186/s12867-017-0091-2
Pubmed ID
Authors

Bingying Deng, Xiang Cheng, Haoming Li, Jianbing Qin, Meiling Tian, Guohua Jin

Abstract

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. The present study aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential roles of identified lncRNAs in the hippocampal neurogenesis. In this study, the profiling suggested that 74 activated and 29 repressed (|log fold-change|>1.5) lncRNAs were differentially expressed between the denervated and the normal hippocampi. Furthermore, differentially expressed lncRNAs associated with neurogenesis were found. According to the tissue-specific expression profiles, and a novel lncRNA (lncRNA2393) was identified as a neural regulator in the hippocampus in this study. The expression of lncRNA2393 was activated in the denervated hippocampus. FISH showed lncRNA2393 specially existed in the subgranular zone of the dentate gyrus in the hippocampus and in the cytoplasm of neural stem cells (NSCs). The knockdown of lncRNA2393 depletes the EdU-positive NSCs. Besides, the increased expression of lncRNA2393 was found to be triggered by the change in the microenvironment. We concluded that expression changes of lncRNAs exists in the microenvironment of denervated hippocampus, of which promotes hippocampal neurogenesis. The identified lncRNA lncRNA2393 expressed in neural stem cells, located in the subgranular zone of the dentate gyrus, which can promote NSCs proliferation in vitro. Therefore, the question is exactly which part of the denervated hippocampus induced the expression of lncRNA2393. Further studies should aim to explore the exact molecular mechanism behind the expression of lncRNA2393 in the hippocampus, to lay the foundation for the clinical application of NSCs in treating diseases of the central nervous system.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 30%
Professor > Associate Professor 2 20%
Student > Master 2 20%
Student > Ph. D. Student 1 10%
Other 1 10%
Other 1 10%
Readers by discipline Count As %
Neuroscience 5 50%
Biochemistry, Genetics and Molecular Biology 3 30%
Agricultural and Biological Sciences 1 10%
Chemistry 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2017.
All research outputs
#2,703,579
of 15,921,004 outputs
Outputs from BMC Molecular Biology
#23
of 278 outputs
Outputs of similar age
#61,111
of 273,094 outputs
Outputs of similar age from BMC Molecular Biology
#1
of 1 outputs
Altmetric has tracked 15,921,004 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 278 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,094 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them