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X Demographics
Mendeley readers
| Title |
Metformin targets multiple signaling pathways in cancer
|
|---|---|
| Published in |
Cancer Communications, January 2017
|
| DOI | 10.1186/s40880-017-0184-9 |
| Pubmed ID | |
| Authors |
Yong Lei, Yanhua Yi, Yang Liu, Xia Liu, Evan T. Keller, Chao-Nan Qian, Jian Zhang, Yi Lu |
| Abstract |
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin-like growth factor, c-Jun N-terminal kinase/mitogen-activated protein kinase (p38 MAPK), human epidermal growth factor receptor-2, and nuclear factor kappaB pathways. In addition, cutting-edge targeting of cancer stem cells by metformin is summarized. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Panama | 1 | 25% |
| Spain | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 146 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 19% |
| Student > Bachelor | 22 | 15% |
| Student > Ph. D. Student | 18 | 12% |
| Researcher | 8 | 5% |
| Lecturer | 7 | 5% |
| Other | 24 | 16% |
| Unknown | 39 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 25% |
| Biochemistry, Genetics and Molecular Biology | 28 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 10% |
| Agricultural and Biological Sciences | 9 | 6% |
| Nursing and Health Professions | 4 | 3% |
| Other | 13 | 9% |
| Unknown | 42 | 29% |