Title |
Possible role of the α7 nicotinic receptors in mediating nicotine’s effect on developing lung – implications in unexplained human perinatal death
|
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Published in |
BMC Pulmonary Medicine, February 2014
|
DOI | 10.1186/1471-2466-14-11 |
Pubmed ID | |
Authors |
Anna M Lavezzi, Melissa F Corna, Graziella Alfonsi, Luigi Matturri |
Abstract |
It is well known that maternal smoking during pregnancy is very harmful to the fetus. Prenatal nicotine absorption, in particular, is associated with alterations in lung development and functions at birth and with respiratory disorders in infancy. Many of the pulmonary disorders are mediated by the interaction of nicotine with the nicotinic receptors (nAChRs), above all with the α7 nAChR subunits that are widely expressed in the developing lung. To determine whether the lung hypoplasia frequently observed in victims of sudden fetal and neonatal death with a smoker mother may result from nicotine interacting with lung nicotinic receptors, we investigated by immunohistochemistry the possible presence of the α7 nAChR subunit overexpression in these pathologies. |
X Demographics
Geographical breakdown
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Canada | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 20% |
Researcher | 8 | 15% |
Student > Master | 5 | 9% |
Professor | 3 | 5% |
Student > Ph. D. Student | 3 | 5% |
Other | 9 | 16% |
Unknown | 16 | 29% |
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Neuroscience | 5 | 9% |
Psychology | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 11% |
Unknown | 17 | 31% |