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Independent prognostic role of human papillomavirus genotype in cervical cancer

Overview of attention for article published in BMC Infectious Diseases, June 2017
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Title
Independent prognostic role of human papillomavirus genotype in cervical cancer
Published in
BMC Infectious Diseases, June 2017
DOI 10.1186/s12879-017-2465-y
Pubmed ID
Authors

Dong Hang, Meiqun Jia, Hongxia Ma, Jing Zhou, Xiaoshuang Feng, Zhangyan Lyu, Jian Yin, Hong Cui, Yin Yin, Guangfu Jin, Zhibin Hu, Hongbing Shen, Kai Zhang, Ni Li, Min Dai

Abstract

Although the correlation of HPV genotype with cervical precursor lesions and invasive cancer has been confirmed, the role of HPV genotype in cervical cancer prognosis is less conclusive. This study aims to systematically investigate the independent prognostic role of HPV genotype in cervical cancer. A total of 306 eligible patients provided cervical cell specimens for HPV genotyping before therapy and had a median follow-up time of 54 months after diagnosis. Survival times were measured from the date of diagnosis to the date of cervical cancer-related death (overall survival, OS) and from the date of diagnosis to the date of recurrence or metastasis (disease free survival, DFS). Log-rank tests and Cox proportional hazard models were performed to evaluate the association between HPV genotype and survival times. A total of 12 types of high-risk HPV were detected and the leading ten types belong to two species: alpha-9 and alpha-7. HPV16 and 18 were the two most common types, with the prevalence of 60.8% and 8.8%, respectively. In the univariate analysis, HPV16-positive cases were associated with better OS (P = 0.037) and HPV16-related species alpha-9 predicted better OS and DFS (both P < 0.01). After adjusting for age, FIGO stage, and therapy, HPV16 showed a hazard ratio (HR) of 0.36 (95% CI: 0.18, 0.74; P = 0.005) for OS, and alpha-9 resulted in a HR of 0.17 (95% CI: 0.08, 0.37; P < 0.001) for OS and 0.32 (95% CI: 0.17, 0.59; P < 0.001) for DFS. HPV genotype poses differential prognoses for cervical cancer patients. The presence of HPV16 and its related species alpha-9 indicates an improved survival.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 13%
Student > Bachelor 4 10%
Student > Postgraduate 4 10%
Student > Doctoral Student 3 8%
Other 3 8%
Other 7 18%
Unknown 14 35%
Readers by discipline Count As %
Medicine and Dentistry 14 35%
Biochemistry, Genetics and Molecular Biology 7 18%
Mathematics 1 3%
Environmental Science 1 3%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 15 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2017.
All research outputs
#20,427,593
of 22,979,862 outputs
Outputs from BMC Infectious Diseases
#6,512
of 7,715 outputs
Outputs of similar age
#275,988
of 317,198 outputs
Outputs of similar age from BMC Infectious Diseases
#143
of 169 outputs
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