Title |
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: Involvement of the RB-microRNA axis
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Published in |
BMC Cancer, February 2014
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DOI | 10.1186/1471-2407-14-57 |
Pubmed ID | |
Authors |
Xianpeng Liu, Xin Gu, Limin Sun, Ashley B Flowers, Alfred W Rademaker, Yiran Zhou, Hiroaki Kiyokawa |
Abstract |
The HECT family ubiquitin ligase Smurf2 regulates cell polarity, migration, division, differentiation and death, by targeting diverse substrates that are critical for receptor signaling, cytoskeleton, chromatin remodeling and transcription. Recent studies suggest that Smurf2 functions as a tumor suppressor in mice. However, no inactivating mutation of SMURF2 has been reported in human, and information about Smurf2 expression in human cancer remains limited or complicated. Here we demonstrate that Smurf2 expression is downregulated in human breast cancer tissues, especially of the triple-negative subtype, and address the mechanism of Smurf2 downregulation in triple-negative breast cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 24% |
Student > Master | 7 | 16% |
Student > Bachelor | 5 | 11% |
Researcher | 5 | 11% |
Student > Postgraduate | 3 | 7% |
Other | 6 | 13% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 27% |
Agricultural and Biological Sciences | 10 | 22% |
Medicine and Dentistry | 9 | 20% |
Neuroscience | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 0 | 0% |
Unknown | 8 | 18% |